Prerequisites: CHEM 333/L. Corequisite: CHEM 334L (all majors), CHEM 334R for Chemistry and Biochemistry majors. Recommended Corequisite: CHEM 334R for all other majors. Continuation of CHEM 333, with an emphasis on mechanisms of organic reactions and synthesis. Attention given to representative compounds of interest in biology and medicine. Lab: Exposure to reactions common in chemical synthesis, including arene substitution, transformations of carbonyl compounds, the Diels-Alder reaction and polymer synthesis. 3 hours lecture per week; one 3-hour lab per week.